Quality of Experience (QoE) has become an increasing topic of research with the proliferation of multimedia services on mobile devices. Previous research studies have focused on proposing objective video quality assessment (VQA) metrics, and evaluating them on generic video content databases that consist mainly of natural clips such as news, sports and movies. This paper investigates the accuracy of VQA metrics to estimate user's QoE for natural and non-natural multimedia clips on mobile devices. The results from a subjective study with 60 participants have shown that well known full-reference VQA metrics such as PSNR, SSIM and VIFp exhibit up to 97% QoE estimation accuracy for non-natural clips, despite not being traditionally recommended ...