Relationship between Helicobacter pylori and Periodontal Diseases: A Meta-Analysis Study and Systematic Review

Objective: The present study aimed at the evaluation of the association between H. pylori and periodontal diseases by systematic review and meta-analysis study. Materials and Methods: We searched databases, including PubMed, SID, Magiran, Google Scholar, and Iranmedex using the following keywords in English: H. pylori, tooth decay, oral infection, dental infection, gingival infection and periodontal diseases. Data was analyzed using a meta-analysis and random effect model. Heterogeneity of studies was assessed using the I-2 index, and data was finally analyzed with STATA (Version 11.2). Results: Among 10 articles reviewed that included 56,334 samples, results showed that association between H. pylori and periodontal diseases was significant with OR (odds ratio) = 1.13 (95 CI: 1.04 to 1.24). Conclusion: The results reveal that H. pylori can be one of the main causes of periodontal diseases. Thus, a novel way should be employed for the complete management of H. pylori infections