The contribution of the tumor stroma to cancer progression has been increasingly recognized. We had previously shown that in human neuroblastoma tumors orthotopically implanted in immunodeficient mice, stromal-derived matrix metalloproteinase-9 (MMP-9) contributes to the formation of a mature vasculature by promoting pericyte recruitment along endothelial cells. Here we show that MMP-9 is predominantly expressed by bone marrow-derived CD45-positive leukocytes. Using a series of bone marrow transplantation experiments in MMP-9(+/+) and MMP-9(-/-) mice xenotransplanted with human neuroblastoma tumors, we show that bone marrow-derived MMP-9 is critical for the recruitment of leukocytes from bone marrow into the tumor stroma and for the integra...
Oral squamous cell carcinoma (OSCC) is one of the most common types of cancers in developing countri...
2015-04-21Bone marrow mesenchymal stromal cells (BMMSC) migrate from the bone marrow into the circul...
MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, pr...
Neuroblastoma is a highly invasive neural crest derived cancer and the second most common solid tumo...
SummaryTumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (...
Advanced stages of neuroblastoma show increased expression of matrix metalloproteinases MMP-2 and MM...
AbstractAccording to established notion, one of the major angiogenesis-inducing factors, pro-matrix ...
Bone marrow-derived mesenchymal stromal cells (BMSCs) respond to a variety of tumor cell-derived sig...
We determined whether host matrix metalloproteinase (MMP) 9 is essential to angiogenesis and to the ...
According to established notion, one of the major angiogenesis-inducing factors, pro-matrix metallop...
We determined whether host matrix metalloproteinase (MMP) 9 is essential to angiogenesis and to the ...
AbstractThe matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and ...
Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor pro...
AbstractThe matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and ...
The matrix metalloproteinases (MMPs) play a key role in normal and pathological angiogenesis by medi...
Oral squamous cell carcinoma (OSCC) is one of the most common types of cancers in developing countri...
2015-04-21Bone marrow mesenchymal stromal cells (BMMSC) migrate from the bone marrow into the circul...
MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, pr...
Neuroblastoma is a highly invasive neural crest derived cancer and the second most common solid tumo...
SummaryTumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (...
Advanced stages of neuroblastoma show increased expression of matrix metalloproteinases MMP-2 and MM...
AbstractAccording to established notion, one of the major angiogenesis-inducing factors, pro-matrix ...
Bone marrow-derived mesenchymal stromal cells (BMSCs) respond to a variety of tumor cell-derived sig...
We determined whether host matrix metalloproteinase (MMP) 9 is essential to angiogenesis and to the ...
According to established notion, one of the major angiogenesis-inducing factors, pro-matrix metallop...
We determined whether host matrix metalloproteinase (MMP) 9 is essential to angiogenesis and to the ...
AbstractThe matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and ...
Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor pro...
AbstractThe matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and ...
The matrix metalloproteinases (MMPs) play a key role in normal and pathological angiogenesis by medi...
Oral squamous cell carcinoma (OSCC) is one of the most common types of cancers in developing countri...
2015-04-21Bone marrow mesenchymal stromal cells (BMMSC) migrate from the bone marrow into the circul...
MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, pr...