Technologies enabling in vivo range verification during proton therapy are actively sought as a means to reduce the clinical safety margins currently adopted to avoid tumor underdosage. In this contribution, we applied the semi-empirical theory of radiation-induced vaporization of superheated liquids to coated nanodroplets. Nanodroplets are injectable phase-change contrast agents that can vaporize into highly echogenic microbubbles to provide contrast in ultrasound images. We exposed nanodroplet dispersions in aqueous phantoms to monoenergetic proton beams of varying energies and doses. Ultrasound imaging of the phantoms revealed that radiation-induced droplet vaporization occurred in regions proximal to the proton Bragg peak. A statistical...
The ultrasound contrast agents currently used in clinics are microbubbles with a large particle size...
Proton therapy has the potential to deposit its energy in tissue with high conformity to the tumor a...
Current tumor chemotherapy is associated with severe side effects caused by adverse effects of the d...
Technologies enabling in vivo range verification during proton therapy are actively sought as a mean...
Purpose Despite the physical benefits of protons over conventional photon radiation in cancer tre...
The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume ...
The potential of proton therapy to improve the conformity of the delivered dose to the tumor volumei...
Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the...
Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the...
Methods allowing for in situ dosimetry and range verification are essential in radiotherapy to reduc...
Purpose: We investigate the vaporization of phase-change ultrasound contrast agents using photon rad...
Objective. External beam radiotherapy is aimed to precisely deliver a high radiation dose to maligna...
The ultrasound contrast agents currently used in clinics are microbubbles with a large particle size...
Proton therapy has the potential to deposit its energy in tissue with high conformity to the tumor a...
Current tumor chemotherapy is associated with severe side effects caused by adverse effects of the d...
Technologies enabling in vivo range verification during proton therapy are actively sought as a mean...
Purpose Despite the physical benefits of protons over conventional photon radiation in cancer tre...
The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume ...
The potential of proton therapy to improve the conformity of the delivered dose to the tumor volumei...
Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the...
Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the...
Methods allowing for in situ dosimetry and range verification are essential in radiotherapy to reduc...
Purpose: We investigate the vaporization of phase-change ultrasound contrast agents using photon rad...
Objective. External beam radiotherapy is aimed to precisely deliver a high radiation dose to maligna...
The ultrasound contrast agents currently used in clinics are microbubbles with a large particle size...
Proton therapy has the potential to deposit its energy in tissue with high conformity to the tumor a...
Current tumor chemotherapy is associated with severe side effects caused by adverse effects of the d...