\(\bf Background\) We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigration of cancer cells through endothelial cell monolayers. \(\bf Methods\) Primary HUVEC were irradiated with 2 or 4 Gy photons at a dose rate of 5 Gy/min. The permeability of an irradiated endothelial monolayer for macromolecules and tumor cells was analyzed in the presence or absence of the ADAM10/17 inhibitors GI254023X and GW280264X. Expression of ADAM10, ADAM17 and VE-Cadherin in endothelial cells was quantified by immunoblotting and qRT. ...
Purpose/Objectives The goal of this study was to assess the effects of ionizing radiation on the ex...
Radiation is the most common treatment of cancer. Minimizing the normal tissue injury, especially th...
International audienceAltered by ionising radiation, the vascular network is considered as a prime t...
\(\bf Background\) We analyzed the changes in permeability of endothelial cell layers after photon ...
Radiotherapy damages tumour cells as well as the microvasculature of solid tumours and surrounding n...
The cellular response to ionizing radiation (IR) depends on tumor cell and microenvironmental factor...
Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an...
It remains controversial whether targeting tumour vasculature can improve radiotherapeutic efficacy....
\(\bf Background:\) Radiotherapy is administered in more than 60% of all solid tumors. Most patients...
Although most small arteriovenous malformations (AVM) are curable, over 90% of large lesions are unt...
The present study reports on a new strategy for selective, radiation therapy-amplified drug delivery...
The effect of radiation therapy on tumour vasculature has been a subject of debate over the years. I...
Background and Purpose: Radiotherapy is an essential tool for cancer treatment. In order to spare no...
International audienceAs it is altered by ionizing radiation, the vascular network is considered as ...
Background: Radiation-induced molecular changes on the endothelial surface of brain arteriovenous ma...
Purpose/Objectives The goal of this study was to assess the effects of ionizing radiation on the ex...
Radiation is the most common treatment of cancer. Minimizing the normal tissue injury, especially th...
International audienceAltered by ionising radiation, the vascular network is considered as a prime t...
\(\bf Background\) We analyzed the changes in permeability of endothelial cell layers after photon ...
Radiotherapy damages tumour cells as well as the microvasculature of solid tumours and surrounding n...
The cellular response to ionizing radiation (IR) depends on tumor cell and microenvironmental factor...
Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an...
It remains controversial whether targeting tumour vasculature can improve radiotherapeutic efficacy....
\(\bf Background:\) Radiotherapy is administered in more than 60% of all solid tumors. Most patients...
Although most small arteriovenous malformations (AVM) are curable, over 90% of large lesions are unt...
The present study reports on a new strategy for selective, radiation therapy-amplified drug delivery...
The effect of radiation therapy on tumour vasculature has been a subject of debate over the years. I...
Background and Purpose: Radiotherapy is an essential tool for cancer treatment. In order to spare no...
International audienceAs it is altered by ionizing radiation, the vascular network is considered as ...
Background: Radiation-induced molecular changes on the endothelial surface of brain arteriovenous ma...
Purpose/Objectives The goal of this study was to assess the effects of ionizing radiation on the ex...
Radiation is the most common treatment of cancer. Minimizing the normal tissue injury, especially th...
International audienceAltered by ionising radiation, the vascular network is considered as a prime t...