The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on viral phylogenies from both partial-pol and viral near full-length genome sequences. We use a unique nationwide cohort of 610 well-characterized HIV-1 subtype-B infected individuals on suppressive ART for a median of 5.4 years. We find that a moderate but significant fraction of the HIV-1 reservoir size 1.5 years after the initiation of ART is explained by genetic factors. At the same time, we find more tentative evidence for the heritability of the lo...
Background: Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to ...
International audienceIn HIV infection, viral rebound after treatment discontinuation is considered ...
HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simpli...
The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on ...
The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on ...
BACKGROUND The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral...
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics a...
BACKGROUND: The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral r...
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics a...
The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir ear...
With over 37 million people living with HIV-1, and over one million new infections occurring each ye...
HIV-1 infection cannot be cured because the virus persists as integrated proviral DNA in long-lived ...
A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is ...
Since the advent of antiretroviral therapy (ART) and the resultant suppression of viraemia in the ma...
Background: Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to ...
International audienceIn HIV infection, viral rebound after treatment discontinuation is considered ...
HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simpli...
The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on ...
The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on ...
BACKGROUND The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral...
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics a...
BACKGROUND: The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral r...
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics a...
The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir ear...
With over 37 million people living with HIV-1, and over one million new infections occurring each ye...
HIV-1 infection cannot be cured because the virus persists as integrated proviral DNA in long-lived ...
A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is ...
Since the advent of antiretroviral therapy (ART) and the resultant suppression of viraemia in the ma...
Background: Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to ...
International audienceIn HIV infection, viral rebound after treatment discontinuation is considered ...
HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simpli...