A 4-item PRECISE-DAPT score for dual antiplatelet therapy duration decision-making
- Costa, Francesco
- van Klaveren, David
- Colombo, Antonio
- Feres, Fausto
- Räber, Lorenz
- Pilgrim, Thomas
- Hong, Myeong-Ki
- Kim, Hyo-Soo
- Windecker, Stephan
- Steyerberg, Ewout W
- Valgimigli, Marco
DOIAbstract
The originally-proposed PRECISE-DAPT score is a 5-item risk score supporting decision-making for dual antiplatelet therapy1 duration after PCI. It is unknown if a simplified version of the score based on 4 factors (age, hemoglobin, creatinine clearance, prior bleeding), and lacking white-blood cell count, retains potential to guide DAPT duration. The 4-item PRECISE-DAPT was used to categorize 10,081 patients who were randomized to short (3-6 months) or long (12-24 months) DAPT regimen according to high (HBR defined by PRECISE-DAPT ≥25 points) or non-high bleeding risk (PRECISE-DAPT<25) status. Long treatment duration was associated with higher bleeding rates in HBR (ARD +2.22% [95% CI +0.53 to +3.90]) but not in non-HBR patients (ARD +0.25%...
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