Synthesis of Poly(ϵ-caprolactone) Microreactors from Freeze-Dried Microspheres

Poly(ϵ-caprolactone) microreactors were prepared by micro-volcanic rupture of freeze dried microspheres. Effects of three synthesis parameters viz polymer concentration, emulsifier concentration and stirring speed on size and morphology of microreactors were examined. Average diameter of microreactors showed substantial increase with increasing polymer concentration and reduced size with increasing polyvinyl alcohol (emulsifier) concentration and stirring speed, respectively. These miniaturised structures have potential applications in immunodiagnosis and drug delivery