Cardiovascular hypertrophy is a common feature of hypertension, but it is not known if this is related only to increased blood pressure or also to non-hemodynamic factors. Indeed, drug treatment of hypertension with hydralazine does reduce blood pressure but not cardiovascular hypertrophy. We used Stroke-prone rats (SHRSP) who are sensitive to salt load in order to better characterize the action of an antihypertensive agent on salt-dependent vascular hypertrophy and change in reactivity of calcium channels. SHRSP were submitted to salt load from 8 to 14 weeks of age with or without lacidipine, a long acting dihydropyridine. We observed that the cardiovascular hypertrophy was attenuated by lacidipine 0.3 mgkg-1 day-1 which did not change hig...
It is widely believed that vascular smooth muscle in spontaneously hypertensive rats (SHR) is prone ...
Background: We have previously shown that essential hypertension in humans and spontaneously hyperte...
PubMedID: 28635325Background: High dietary salt, as well as renal mass reduction, is known to decrea...
Cardiovascular hypertrophy is a common feature of hypertension, but is is not known if this is relat...
Stroke-prone spontaneously hypertensive rats receiving a high salt diet were orally treated by the c...
1. The tissue-protective effects of calcium channel blockers in hypertension are not well dissociate...
Endothelium-dependent vasorelaxation is defective in hypertensive rats, especially in conduit arteri...
OBJECTIVE: To analyze the effect of the long-acting calcium channel blocker lacidipine on cardiovasc...
We investigated the influence of salt loading on the renal and cardiac production of endothelin-1 (E...
The concept that calcium ions can have pathogenetic potential when they accumulate excessively into ...
It appears that the beneficial action of calcium channel blockers (CCBs) in hypertension may be rela...
The stroke-prone spontaneously hypertensive rat (SHRSP) is a strain with high incidence of cerebrova...
Endothelium-dependent responses are impaired in various models of hypertension. The effects of antih...
SUMMARY This study investigated vascular responsiveness in stroke-prone spontaneously hyper-tensive ...
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (...
It is widely believed that vascular smooth muscle in spontaneously hypertensive rats (SHR) is prone ...
Background: We have previously shown that essential hypertension in humans and spontaneously hyperte...
PubMedID: 28635325Background: High dietary salt, as well as renal mass reduction, is known to decrea...
Cardiovascular hypertrophy is a common feature of hypertension, but is is not known if this is relat...
Stroke-prone spontaneously hypertensive rats receiving a high salt diet were orally treated by the c...
1. The tissue-protective effects of calcium channel blockers in hypertension are not well dissociate...
Endothelium-dependent vasorelaxation is defective in hypertensive rats, especially in conduit arteri...
OBJECTIVE: To analyze the effect of the long-acting calcium channel blocker lacidipine on cardiovasc...
We investigated the influence of salt loading on the renal and cardiac production of endothelin-1 (E...
The concept that calcium ions can have pathogenetic potential when they accumulate excessively into ...
It appears that the beneficial action of calcium channel blockers (CCBs) in hypertension may be rela...
The stroke-prone spontaneously hypertensive rat (SHRSP) is a strain with high incidence of cerebrova...
Endothelium-dependent responses are impaired in various models of hypertension. The effects of antih...
SUMMARY This study investigated vascular responsiveness in stroke-prone spontaneously hyper-tensive ...
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (...
It is widely believed that vascular smooth muscle in spontaneously hypertensive rats (SHR) is prone ...
Background: We have previously shown that essential hypertension in humans and spontaneously hyperte...
PubMedID: 28635325Background: High dietary salt, as well as renal mass reduction, is known to decrea...