Training improves the electrophysiological properties of lumbar neurons and locomotion after thoracic spinal cord injury in rats.
- Beaumont, Eric
- Kaloustian, Sevan
- Rousseau, Guy
- Cormery, Bruno
DOIAbstract
The aim of the present study was to evaluate the effect of a stepping-based rehabilitation program in voluntary wheel cages on the functional recovery and electrophysiological properties of neurons in the rat lumbar spinal cord after compressive thoracic (T10) spinal cord injury (SCI). A significant decrease in stance/swing duration and the number of limbs simultaneously in the stance phase was seen in trained compared to sedentary rats at 28 days after SCI (p<0.05). These kinematic improvements were associated with a significant increase in the amplitude of extracellular recordings from the tibial motoneuron pool in response to descending neuronal drive as well as significant amelioration of electrophysiological properties assessed from in...
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