Persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) is a heterogeneous disorder characterized by profound hypoglycaemia due to inappropriate hypersecretion of insulin. An important diagnostic goal is to distinguish patients with a focal hyperplasia of islet cells of the pancreas (FoPHHI) from those with a diffuse abnormality of islets (DiPHHI), because the management differs significantly. The intriguing similarity between islet cell hyperplasia and tumourigenesis prompted us to investigate whether the imprinted genes in the 11p15 region are involved. Results showed that diffuse forms are caused by constitutional homozygous or compound heterozygous mutations of the SUR1 gene. In contrast, focal forms are caused by loss of the mater...
International audienceCongenital hyperinsulinism (CHI) is biochemically characterised by the dysregu...
Persistent hyperinsulinism is the most common cause of recurrent hypoglycemia in infancy because of ...
Mosaic genome-wide paternal uniparental disomy (GW-pUPD) is a rarely recognised disorder. The phenot...
Congenital hyperinsulinism, or persistent hyperinsulinemic hypoglycemia of infancy (PHHI), is a gluc...
Two types of histopathological lesions, a focal adenomatous hyperplasia of islet cells of the pancre...
Congenital hyperinsulinism (CHI), previously named persistent hyperinsulinemic hypoglycemia of infan...
Sporadic persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or nesidioblastosis is a heterog...
Persistent hyperinsulinemic hypoglycaemia of infancy (PHHI) is heterogeneous condition often due to ...
Persistent hyperinsulinemic hypoglycaemia of infancy (PHHI) is the most frequent cause of hypoglycae...
BACKGROUND: Congenital hyperinsulinism (CHI) is associated with focal hyperplasia of endocrine tissu...
Background: Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia. Histologically, ...
Congenital hyperinsulinism (CHI), characterized by profound hypoglycaemia related to inappropriate i...
BACKGROUND: Congenital hyperinsulinism and Beckwith-Wiedemann syndrome both lead to beta islet hyper...
N eonatal hyperinsulinism is the mostimportant cause of hypoglycemia ininfancy (1,2). The inappropri...
Morphological studies of the pancreas in persistent hyperinsulinemic hypoglycemia of infancy (PHHI) ...
International audienceCongenital hyperinsulinism (CHI) is biochemically characterised by the dysregu...
Persistent hyperinsulinism is the most common cause of recurrent hypoglycemia in infancy because of ...
Mosaic genome-wide paternal uniparental disomy (GW-pUPD) is a rarely recognised disorder. The phenot...
Congenital hyperinsulinism, or persistent hyperinsulinemic hypoglycemia of infancy (PHHI), is a gluc...
Two types of histopathological lesions, a focal adenomatous hyperplasia of islet cells of the pancre...
Congenital hyperinsulinism (CHI), previously named persistent hyperinsulinemic hypoglycemia of infan...
Sporadic persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or nesidioblastosis is a heterog...
Persistent hyperinsulinemic hypoglycaemia of infancy (PHHI) is heterogeneous condition often due to ...
Persistent hyperinsulinemic hypoglycaemia of infancy (PHHI) is the most frequent cause of hypoglycae...
BACKGROUND: Congenital hyperinsulinism (CHI) is associated with focal hyperplasia of endocrine tissu...
Background: Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia. Histologically, ...
Congenital hyperinsulinism (CHI), characterized by profound hypoglycaemia related to inappropriate i...
BACKGROUND: Congenital hyperinsulinism and Beckwith-Wiedemann syndrome both lead to beta islet hyper...
N eonatal hyperinsulinism is the mostimportant cause of hypoglycemia ininfancy (1,2). The inappropri...
Morphological studies of the pancreas in persistent hyperinsulinemic hypoglycemia of infancy (PHHI) ...
International audienceCongenital hyperinsulinism (CHI) is biochemically characterised by the dysregu...
Persistent hyperinsulinism is the most common cause of recurrent hypoglycemia in infancy because of ...
Mosaic genome-wide paternal uniparental disomy (GW-pUPD) is a rarely recognised disorder. The phenot...