Characterization of the CtsR stress response regulon in Lactobacillus plantarum.
- Fiocco, Daniela
- Capozzi, Vittorio
- Collins, Michael
- Gallone, Anna
- Hols, Pascal
- Guzzo, Jean
- Weidmann, Stephanie
- Rieu, Aurélie
- Msadek, Tarek
- Spano, Giuseppe
DOIAbstract
Lactobacillus plantarum ctsR was characterized. ctsR was found to be cotranscribed with clpC and induced in response to various abiotic stresses. ctsR deletion conferred a heat-sensitive phenotype with peculiar cell morphological features. The transcriptional pattern of putative CtsR regulon genes was examined in the DeltactsR mutant. Direct CtsR-dependent regulation was demonstrated by DNA-binding assays using recombinant CtsR and the promoters of ctsR-clpC operon and hsp1
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