No PDGF receptor signal in pericytes without endosialin?

Solid tumors contain non-transformed cells of critical importance for disease progression. These cells form the tumor stroma, including blood vessel and fibroblasts. Being more genetically stable than cancer cells, stromal cells have drawn much interest as potential therapeutic targets, leading to the concepts of anti-angiogenic and anti-stromal drugs. In this context, researchers have been seeking new stromal cell markers. Endosialin (CD248, TEM-1) and PDGF Receptor beta are two of them