Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase

Monothiohydantoin 3a is made in seven steps front 1,4-diiodobenzene and is shown to be an inhibitor of fatty acid amide hydrolase (IC50) = 23.4 +/- 1.1 mu M). The key step in the sequence involves a microwave-assisted four- component reaction that makes the 5,5'-disubstituted hydantoin nucleus by the sequential formation of two C-C and two C-N bonds. (C) 2008 Elsevier Ltd. All rights reserved