Trifluoromethylated Pyrimidines Starting From Beta-trifluoroacetyl-lactams, Beta-trifluoroacetyl-lactone and Beta-trifluoroacetyl-cyclanone

A synthesis of trifluoromethylated pyrimidines from beta-trifluoroacetyl-lactams and -benzolactams is accomplished by reaction with benzamidine as bis-nucleophile. This condensation is also extended to cyclic trifluoromethylated 1,3-diketones and 3-aroyl-2-pyrrolidinones