Interactions of aminoglycosides with phosphatidylinositol - a N-15 nuclear-magnetic-resonance study

The N-15 NMR spectra of eight aminoglycosides were interpreted. The effect of mixing 20 mol.% of various aminoglycosides with phosphatidylinositol in aqueous dispersion was studied by N-15 NMR, and correlations were found between the degree of interaction of the aminoglycoside for phosphatidylinositol and the calculated energy of interaction of the antibiotic with the negatively charged phospholipid and the inhibitory potency of the drug towards lysosomal phospholipase A1, a critical parameter in the nephrotoxic potential of aminoglycosides