Add to ORKGBACKGROUND: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain that plays a central role in microglia activation in response to AD brain pathologies. Whether higher TREM2-related microglia activity modulates the risk to develop clinical AD is an open question. Thus, the aim of the current study was to assess whether higher sTREM2 attenuates the effects of ApoE4-effects on future cognitive decline and neurodegeneration. METHODS: We included 708 subjects ranging from cognitively normal (CN, n = 221) to mild cognitive impairment (MCI, n = 414) and AD dementia (n = 73) fro...
Background and purpose Neuroinflammation plays a role in the aetiopathogenesis of Alzheimer's diseas...
A coding missense mutation (rs3747742) in triggering receptor expressed on myeloid cell-like 2 (TREM...
Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have...
Background: The Apolipoprotein E ϵ4 allele (i.e. ApoE4) is the strongest genetic risk factor for spo...
BackgroundThe Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for spora...
Background: The discovery that heterozygous missense mutations in the gene encoding triggering recep...
Altres ajuts: This publication is part of the AETIONOMY project (Organising Mechanistic Knowledge ab...
Microglia activation is the brain\u27s major immune response to amyloid plaques in Alzheimer\u27s di...
Background: The discovery that heterozygous missense mutations in the gene encoding triggering recep...
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of ...
A coding missense mutation (rs3747742) in triggering receptor expressed on myeloid cell-like 2 (TREM...
Abstract Background TREM2 is a transmembrane receptor that is predominantly expressed by microglia i...
BackgroundTREM2 is a transmembrane receptor that is predominantly expressed by microglia in the cent...
Background Alzheimer’s disease (AD) neuropathology is associated with neuroinflammat...
Abstract Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's...
Background and purpose Neuroinflammation plays a role in the aetiopathogenesis of Alzheimer's diseas...
A coding missense mutation (rs3747742) in triggering receptor expressed on myeloid cell-like 2 (TREM...
Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have...
Background: The Apolipoprotein E ϵ4 allele (i.e. ApoE4) is the strongest genetic risk factor for spo...
BackgroundThe Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for spora...
Background: The discovery that heterozygous missense mutations in the gene encoding triggering recep...
Altres ajuts: This publication is part of the AETIONOMY project (Organising Mechanistic Knowledge ab...
Microglia activation is the brain\u27s major immune response to amyloid plaques in Alzheimer\u27s di...
Background: The discovery that heterozygous missense mutations in the gene encoding triggering recep...
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of ...
A coding missense mutation (rs3747742) in triggering receptor expressed on myeloid cell-like 2 (TREM...
Abstract Background TREM2 is a transmembrane receptor that is predominantly expressed by microglia i...
BackgroundTREM2 is a transmembrane receptor that is predominantly expressed by microglia in the cent...
Background Alzheimer’s disease (AD) neuropathology is associated with neuroinflammat...
Abstract Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's...
Background and purpose Neuroinflammation plays a role in the aetiopathogenesis of Alzheimer's diseas...
A coding missense mutation (rs3747742) in triggering receptor expressed on myeloid cell-like 2 (TREM...
Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have...