Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn’s disease

Diederen, Kay
Li, Jia V.
Donachie, Gillian E.
de Meij, Tim G.
de Waart, Dirk R.
Hakvoort, Theodorus B. M.
Kindermann, Angelika
Wagner, Josef
Auyeung, Victoria
te Velde, Anje A.
Heinsbroek, Sigrid E. M.
Benninga, Marc A.
Kinross, James
Walker, Alan W.
de Jonge, Wouter J.
Seppen, Jurgen

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Publication date

November 2020

DOI

10.1038/s41598-020-75306-z

Publisher

Springer Science and Business Media LLC

Journal

Scientific Reports

Language

English

Abstract

GD and AWW receive core funding support from the Scottish Government’s Rural and Environmental Science and Analytical Services (RESAS) Division. JW was funded by the Wellcome Trust [Grant No. 098051]. JVL is funded by MRC New Investigator Grant (MR/P002536/1) and ERC Starting Grant (715662). JK is funded by NIHR: II-OL-1116-10027, NIH: R01-CA204403-01A1, Horizon H2020: ITN GROWTH. Imperial Biomedical Research Centre, SAGES research grant. Infrastructure support for this research was provided by the NIHR Imperial biomedical Research Centre (BRC). Microbiota analyses were carried out using the Maxwell computer cluster at the University of Aberdeen. We thank the Illumina MiSeq team at the Wellcome Sanger Institute for their assistance. This wo...