Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial.
- Davis, Stephen M
- Donnan, Geoffrey A
- Parsons, Mark W
- Levi, Christopher
- Butcher, Kenneth S
- Peeters, André
- Barber, P Alan
- Bladin, Christopher
- De Silva, Deidre A
- Byrnes, Graham
- Chalk, Jonathan B
- Fink, John N
- Kimber, Thomas E
- Schultz, David
- Hand, Peter J
- Frayne, Judith
- Hankey, Graeme
- Muir, Keith
- Gerraty, Richard
- Tress, Brian M
- Desmond, Patricia M
DOIAbstract
Alteplase was non-significantly associated with lower infarct growth and significantly associated with increased reperfusion in patients who had mismatch. Because reperfusion was associated with improved clinical outcomes, phase III trials beyond 3 h after treatment are warranted
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