Add to ORKGThese past years, we focused our researches on the identification of novel, potential peptide targets for cancer immunotherapy. Amongst the peptides we identified, two are composed of fragments originally distant in the parental protein and are produced by a novel mechanism termed peptide splicing. The peptide splicing reaction takes place in the proteasome and occurs by transpeptidation. Here, we describe the discovery of this new mechanism of production of antigenic peptides
Various new aspects of antigen processing have been uncovered through the study of tumor antigens. O...
By tying peptides originally distant in parental proteins, the proteasome can generate spliced pepti...
In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor...
These past years, we focused our researches on the identification of novel, potential peptide target...
The proteasome is the major protease responsible for the production of antigenic peptides recognized...
Antigens presented by MHC class I molecules to CD8+ T lymphocytes consist of peptides of 8-11 amino ...
Peptide splicing is a novel mechanism of production of peptides relying on the proteasome and involv...
CD8+ cytolytic T lymphocytes are essential players of anti-tumor immune responses. On tumors, they r...
Peptide splicing is a newly described mode of production of antigenic peptides presented by MHC clas...
Peptide splicing allows the production of antigenic peptides composed of two fragments initially non...
By tying peptide fragments originally distant in parental proteins, the proteasome can generate spli...
By tying peptide fragments originally distant in parental proteins, the proteasome can generate spli...
CD8+ T cell specificity depends on the recognition of MHC class I-epitope complexes at the cell surf...
Peptide splicing, in which two distant parts of a protein are excised and then ligated to form a nov...
CD8+ T cell specificity depends on the recognition of MHC class I-epitope complexes at the cell surf...
Various new aspects of antigen processing have been uncovered through the study of tumor antigens. O...
By tying peptides originally distant in parental proteins, the proteasome can generate spliced pepti...
In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor...
These past years, we focused our researches on the identification of novel, potential peptide target...
The proteasome is the major protease responsible for the production of antigenic peptides recognized...
Antigens presented by MHC class I molecules to CD8+ T lymphocytes consist of peptides of 8-11 amino ...
Peptide splicing is a novel mechanism of production of peptides relying on the proteasome and involv...
CD8+ cytolytic T lymphocytes are essential players of anti-tumor immune responses. On tumors, they r...
Peptide splicing is a newly described mode of production of antigenic peptides presented by MHC clas...
Peptide splicing allows the production of antigenic peptides composed of two fragments initially non...
By tying peptide fragments originally distant in parental proteins, the proteasome can generate spli...
By tying peptide fragments originally distant in parental proteins, the proteasome can generate spli...
CD8+ T cell specificity depends on the recognition of MHC class I-epitope complexes at the cell surf...
Peptide splicing, in which two distant parts of a protein are excised and then ligated to form a nov...
CD8+ T cell specificity depends on the recognition of MHC class I-epitope complexes at the cell surf...
Various new aspects of antigen processing have been uncovered through the study of tumor antigens. O...
By tying peptides originally distant in parental proteins, the proteasome can generate spliced pepti...
In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor...