Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course
- Put, Natalie
- Van Roosbroeck, Katrien
- Konings, Peter
- Meeus, Peter
- Brusselmans, Caroline
- Rack, Katrina
- Gervais, Carine
- Nguyen-Khac, Florence
- Chapiro, Elise
- Radford-Weiss, Isabelle
- Struski, Stéphanie
- Dastugue, Nicole
- Gachard, Nathalie
- Lefebvre, Christine
- Barin, Carole
- Eclache, Virginie
- Fert-Ferrer, Sandra
- Laibe, Sophy
- Mozziconacci, Marie-Joëlle
- Quilichini, Benoît
- Poirel, Hélène
- Wlodarska, Iwona
- Hagemeijer, Anne
- Moreau, Yves
- Vandenberghe, Peter
- Michaux, Lucienne
DOIAbstract
Translocations involving MYC are rare in chronic lymphocytic leukemia (CLL), and up to now, their prognostic significance remains unclear. We report the characteristics of 21 patients with CLL and nine patients with prolymphocytic leukemia (PLL), diagnosed in multiple centers (n = 13), which showed an MYC translocation demonstrated by fluorescence in situ hybridization. The prevalence was estimated to be <1%. Advanced age and male predominance were observed. Morphological analysis frequently revealed the presence of prolymphocytes. A typical "CLL-immunophenotype" was found in four of nine cases with PLL. Moreover, CD5 and CD23 were frequently expressed in PLL. The latter findings are atypical for PLL and may suggest transformation or progre...
Add to ORKG