Extensive deep vein thrombosis as a complication of testicular cancer treated with the BEP protocol (bleomycin, etoposide and cisplatin): Case report

Context: There are no reports in the literature of massive deep venous thrombosis (DVT) associated with cisplatin, bleomycin and etoposide (BEP) cancer treatment. Case Report: The patient was a 18-year-old adolescent with a nonseminomalous germ cell tumor of the right testicle, with the presence of pulmonary, liver, and massive retroperitoneal metastoses. Following radical orchiectomy, the patient started chemotherapy according to the BEP protocol (without routine prophylaxis for DVT). On day 4 of the first cycle, massive DVT was diagnosed, extending from both poplifeal veins up to the thoracic segment of the inferior vena cava. Thombolytic therapy with streptokinase was immediately diately started. On day 2 of the thrombolytic therapy, the patient developed acute renal failure, due to extension of the Thrombosis to the renal veins. Streptokinase was continued for six days and the outcome was remarkably favorable. Copyright © 2006, Associação Paulista de Medicina