A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate

  • Caputi, L
  • Rejzek, M
  • Louveau, T
  • O’Neill, EC
  • Hill, L
  • Osbourn, A
  • Field, RA
Publication date
January 2013
Publisher
Elsevier BV

Abstract

In connection with prospective 18F-PET imaging studies, the potential for enzymatic synthesis of fluorine-labelled glycosides of small molecules was investigated. Approaches to the enzymatic synthesis of anomeric phosphates of d-gluco-configured fluorosugars proved ineffective. In contrast, starting in the d-galacto series and relying on the consecutive action of Escherichia coli galactokinase (GalK), galactose-1-phosphate uridylyltransferase (GalPUT), uridine-5′-diphosphogalactose 4-epimerase (GalE) and oat root glucosyltransferase (SAD10), a quick and effective synthesis of 6-deoxy-6-fluoro-d-glucosyl N-methylanthranilate ester was achieved

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Topics

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esterChemical compound
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galactokinaseBiomolecule
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uridineChemical substance
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