Introduction: Diseased tendons are characterised by fibrotic scar tissue, which adversely affects tendon structure and function and increases the likelihood of reinjury. The mechanisms and expression profiles of fibrosis in diseased tendon is understudied compared to pulmonary and renal tissues, where TGFβ and its associated superfamily are known to be key drivers of fibrosis and modulate extracellular matrix homeostasis. We hypothesised that differential expression of TGFβ superfamily members would exist between samples of human rotator cuff tendons with established disease compared to healthy control tendons. Methods: Healthy and diseased rotator cuff tendons were collected from patients presenting to an orthopaedic referral centre. Dise...
none7siCollagen VI is a microfibrillar collagen with a potential regulatory role in tendon repair me...
Tendons transfer forces from muscle to bone and are vital to movement. Unfortunately, tendons are in...
Chronic tendon lesions are degenerative conditions and may represent a failure to repair or remodel ...
Introduction: Diseased tendons are characterised by fibrotic scar tissue, which adversely affects te...
Diseased tendons are characterised by fibrotic scar tissue, which adversely affects tendon structure...
Diseased tendons are characterised by fibrotic scar tissue, which adversely affects tendon structure...
Shoulder pain is common, often caused by rotator cuff inflammation and usually heals by fibrotic rep...
Tendon disease begins with inflammation and results in an incomplete repair with fibrosis. IL- 1β is...
Background Tendon disease is characterized by the development of fibrosis. Transforming growth facto...
Background Tendon disease is characterized by the development of fibrosis. Transforming growth facto...
Flexor tendon injuries are among the most challenging problems for hand surgeons and tissue engineer...
Flexor tendon injuries are among the most challenging problems for hand surgeons and tissue engineer...
Despite decades of research, fibrosis still remains a significant challenge for medicine in many dif...
BACKGROUND: Tendinopathy is a clinical problem for which treatment shows mixed results and treatmen...
<p>Left panel (A, D): Effect of de-tensioning, mid panel (B, E): Effect of TGF-β1 on tensioned 3D te...
none7siCollagen VI is a microfibrillar collagen with a potential regulatory role in tendon repair me...
Tendons transfer forces from muscle to bone and are vital to movement. Unfortunately, tendons are in...
Chronic tendon lesions are degenerative conditions and may represent a failure to repair or remodel ...
Introduction: Diseased tendons are characterised by fibrotic scar tissue, which adversely affects te...
Diseased tendons are characterised by fibrotic scar tissue, which adversely affects tendon structure...
Diseased tendons are characterised by fibrotic scar tissue, which adversely affects tendon structure...
Shoulder pain is common, often caused by rotator cuff inflammation and usually heals by fibrotic rep...
Tendon disease begins with inflammation and results in an incomplete repair with fibrosis. IL- 1β is...
Background Tendon disease is characterized by the development of fibrosis. Transforming growth facto...
Background Tendon disease is characterized by the development of fibrosis. Transforming growth facto...
Flexor tendon injuries are among the most challenging problems for hand surgeons and tissue engineer...
Flexor tendon injuries are among the most challenging problems for hand surgeons and tissue engineer...
Despite decades of research, fibrosis still remains a significant challenge for medicine in many dif...
BACKGROUND: Tendinopathy is a clinical problem for which treatment shows mixed results and treatmen...
<p>Left panel (A, D): Effect of de-tensioning, mid panel (B, E): Effect of TGF-β1 on tensioned 3D te...
none7siCollagen VI is a microfibrillar collagen with a potential regulatory role in tendon repair me...
Tendons transfer forces from muscle to bone and are vital to movement. Unfortunately, tendons are in...
Chronic tendon lesions are degenerative conditions and may represent a failure to repair or remodel ...