A library of 32 members of 3,4-dihydro-3-oxo-2H-1,4-benzoxazines has been synthesized from two substituted 2-aminophenols via microwave-assisted one-pot regioselective annulation of 2-bromoalkanoates and subsequent Suzuki-Miyaura cross-coupling of the chloro-substituted scaffolds. The latter transformation was carried out using our Aphos-Pd(OAc)(2) catalyst and the coupling of the aryl chlorides with arylboronic acids proceeded under mild reaction conditions at 60-80 degrees C in THF-H2O (10:1) in the presence of K3PO4 center dot 3H(2)O as the base to furnish the corresponding biaryl products in 80-98% yields. (C) 2013 Elsevier Ltd. All rights reserved
A number of novel benzimidazolium salts having aryl substituents such as N-phenyl, 4-chlorophenyl an...
There is a demand for methodology that can rapidly produce families of catalysts for catalyst-struct...
Four monodentate benzoferrocenyl phosphines were studied as supporting ligands in palladium-catalyze...
An efficient and general synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines under controlled...
A protocol for regioselective one-pot synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines und...
To introduce the biaryl structure as a triazine functionality, we have developed a new synthetic rou...
Aryl chlorides are efficiently cross-coupled with aryl boronic acids using 0.25 mol% of 4,4′-dichlor...
4-Aminophthalazin-1(2H)-ones (APOs) are underexplored heterocyclic compounds with promising and dive...
A family of air-stable amide-derived phosphine (Aphos) ligands engineered on simple N,N-dialkyl aryl...
A library of (piperazin-1-ylmethyl)biaryls has been synthesized from tert-butyl 4-(3- and 4-(4,4,5,5...
A review covering the literature until April 2008 concerning organometallic reactions to funcionalis...
Carbon-carbon bond formation reactions are some of the most important processes in chemistry, which ...
The one-pot U-4CR and intramolecular O-alkylation sequence starting from 2-aminophenols in combinati...
A two-step protocol involving Pd-catalyzed cyclization of readily accessible p-bromophenyl-aldimines...
[GRAPHICS] Benzylboranes are noticeably uncommon partners within Suzuki-Miyaura coupling reactions. ...
A number of novel benzimidazolium salts having aryl substituents such as N-phenyl, 4-chlorophenyl an...
There is a demand for methodology that can rapidly produce families of catalysts for catalyst-struct...
Four monodentate benzoferrocenyl phosphines were studied as supporting ligands in palladium-catalyze...
An efficient and general synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines under controlled...
A protocol for regioselective one-pot synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines und...
To introduce the biaryl structure as a triazine functionality, we have developed a new synthetic rou...
Aryl chlorides are efficiently cross-coupled with aryl boronic acids using 0.25 mol% of 4,4′-dichlor...
4-Aminophthalazin-1(2H)-ones (APOs) are underexplored heterocyclic compounds with promising and dive...
A family of air-stable amide-derived phosphine (Aphos) ligands engineered on simple N,N-dialkyl aryl...
A library of (piperazin-1-ylmethyl)biaryls has been synthesized from tert-butyl 4-(3- and 4-(4,4,5,5...
A review covering the literature until April 2008 concerning organometallic reactions to funcionalis...
Carbon-carbon bond formation reactions are some of the most important processes in chemistry, which ...
The one-pot U-4CR and intramolecular O-alkylation sequence starting from 2-aminophenols in combinati...
A two-step protocol involving Pd-catalyzed cyclization of readily accessible p-bromophenyl-aldimines...
[GRAPHICS] Benzylboranes are noticeably uncommon partners within Suzuki-Miyaura coupling reactions. ...
A number of novel benzimidazolium salts having aryl substituents such as N-phenyl, 4-chlorophenyl an...
There is a demand for methodology that can rapidly produce families of catalysts for catalyst-struct...
Four monodentate benzoferrocenyl phosphines were studied as supporting ligands in palladium-catalyze...