Several naturally occuring monoflavonoids, isolated from Scutellaria baicalensis Georgi using silica gel and LH-20 chromatography, inhibited [3H] flunitrazepam binding to the central benzodiazepine receptors (BDZ-Rs) with high to moderately low binding affinity. The most potent one is 5,7,2’-trihydroxy-6,8-dimethoxyflavone (K36) with a Ki of 7.7 nM and the weakest one is baicalin with a Ki of 77.1 μM. The functional properties of wogonin (Ki=1.06 μM) and K36 were determined by electrophysiological studies, employing dorsal root ganglion (DRG) neurons and recombinant GABAA receptor functionally expressed in Xenopus laevis oocytes. Wogonin and K36 brought about an enhancement of the GABA-activated current, which could be reversed by the co-a...
The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test th...
Phellopterin, a naturally occurring furanocoumarin found in the roots of Angelica dahurica, inhibits...
The use of phytomedicinal remedies has increased during the last decades thanks to the relative low ...
The search for novel anxiolytics devoid of undesirable side-effects typical of classical benzodiazep...
A radioreceptor binding assay was used to guide the isolation of four chemical constituents in the o...
Screening of traditional medicines has proven invaluable to drug development and discovery. Utilizin...
Benzodiazepine receptor (BDZR) ligands were isolated from medicinal herbal extracts of Scutelluria b...
As part of an effort to identify naturally occurring GABA A receptor benzodiazepine binding site (BD...
Twenty-six flavonoids were isolated from Scutellaria baicalensis. Their affinities for the benzodiaz...
Background: Clinical and experimental studies support the therapeutic potential of Withania somnifer...
A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'...
The search for flavonoids with novel therapeutic effects has been intense. Wogonin, as a naturally e...
Classical benzodiazepines (BZs) are the most widely prescribed drugs acting on the central nervous s...
Classical benzodiazepines (BZs) are the most widely prescribed drugs acting on the central nervous s...
Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ...
The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test th...
Phellopterin, a naturally occurring furanocoumarin found in the roots of Angelica dahurica, inhibits...
The use of phytomedicinal remedies has increased during the last decades thanks to the relative low ...
The search for novel anxiolytics devoid of undesirable side-effects typical of classical benzodiazep...
A radioreceptor binding assay was used to guide the isolation of four chemical constituents in the o...
Screening of traditional medicines has proven invaluable to drug development and discovery. Utilizin...
Benzodiazepine receptor (BDZR) ligands were isolated from medicinal herbal extracts of Scutelluria b...
As part of an effort to identify naturally occurring GABA A receptor benzodiazepine binding site (BD...
Twenty-six flavonoids were isolated from Scutellaria baicalensis. Their affinities for the benzodiaz...
Background: Clinical and experimental studies support the therapeutic potential of Withania somnifer...
A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'...
The search for flavonoids with novel therapeutic effects has been intense. Wogonin, as a naturally e...
Classical benzodiazepines (BZs) are the most widely prescribed drugs acting on the central nervous s...
Classical benzodiazepines (BZs) are the most widely prescribed drugs acting on the central nervous s...
Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ...
The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test th...
Phellopterin, a naturally occurring furanocoumarin found in the roots of Angelica dahurica, inhibits...
The use of phytomedicinal remedies has increased during the last decades thanks to the relative low ...