A novel nano-micro structured octacalcium phosphate/protein composite coating on titanium by using an electrochemically induced deposition

In this study, a novel nano-micro structured octacalcium phosphate/protein (OCP/protein) composite coating has been successfully constructed on titanium substrate by using an electrochemically induced deposition technique. The structure and composition of the composite coating were investigated by XRD, XPS, SEM and FTIR. It is shown that the composite coating consists of OCP and protein with a highly ordered and hierarchically porous structure in nano-micro scale, similar to the natural bone structure. The nanoindentation experiment proves a good mechanical property for the OCP/protein composite coating on titanium substrate. In the osteoblast cell culture in vitro, the cell adhesion for the OCP/protein composite coating is observed to be greatly improved. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 87A: 698-705, 200