High Serum Level of Neopterin is a Risk Factor of Patients with Heart Failure

Serum neopterin concentration was measured in 198 patients with chronic heart failure (CHF) and 62 control subjects by ELISA. Patients were prospectively followed during a median follow-up period of 745 days with end points of cardiac death or re-hospitalization due to progressive heart failure. Serum concentration of neopterin increased with advancing New York Heart Association (NYHA) functional class (P < 0.001). High neopterin group had a significantly higher incidence of cardiac events than low neopterin group (P < 0.0001). In the multivariate Cox analysis, serum neopterin concentration was an independent risk factor for cardiac events (hazard ratio 1.70, 95%CI 1.16-2.50, P = 0.0068). Serum neopterin concentration is a novel prognostic marker for CHF