Towards healthy aging : the effect of senolytics on age-related diseases

Cellular senescence is a state of cell cycle arrest that takes place in response to damaging stimuli such as telomere shortening. Despite their short-term beneficial effects, senescent cells have been proven to accumulate during aging, contributing to a wide range of age-related pathologies. Because of this, senolysis, a novel therapeutic approach based on senescence-targeted clearance, has rapidly emerged as a treatment candidate to achieve healthy-aging. This poster focuses on the recently discovered senolytic drug combination dasatinib plus quercetin, which has shown protective effects in a plethora of aging phenotypes such as neurological, metabolic, cardiovascular, endocrine or physical conditions associated with old age. Whether senolytics will become the Holy Grail of aging is still to be seen, but they are sure to bring geroscience to an exciting point in which important progress on the study of aging will be made