In neurons, lysosomes regulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor levels at the plasma membrane, although their presence at distal dendrites is controversial. In this issue, Goo et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201704068) show for the first time that neuronal activity positions lysosomes at the dendritic spines to facilitate synaptic remodeling through local protein degradation
Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spa...
Synapses are often far from their cell bodies and must cope largely independently with dysfunctional...
Like all cells, neurons are made of proteins that have characteristic synthesis and degradation prof...
In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily r...
Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, ...
A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degrad...
Each neuron in the mammalian central nervous system makes up to ten thousand synaptic connections wi...
Ubiquitin-dependent receptor endocytosis and subsequent endocytic sorting to the lysosome for degrad...
My dissertation research focused on studying activity-dependent protein degradation in neurons prima...
The lysosome is canonically known as a major organelle for protein degradation and nutrient sensing ...
Lysosomes have traditionally been viewed as degradative organelles, though a growing body of evidenc...
Abstract: Compartmentalization of the membrane is essential for cells to perform highly specific tas...
Mechanisms of local protein quality control in the presynaptic nerve terminal remain largely unknown...
Cellular compartmentalization and intracellular transport mechanisms are important to establish and ...
Cellular compartmentalization and intracellular transport mechanisms are important to establish and ...
Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spa...
Synapses are often far from their cell bodies and must cope largely independently with dysfunctional...
Like all cells, neurons are made of proteins that have characteristic synthesis and degradation prof...
In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily r...
Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, ...
A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degrad...
Each neuron in the mammalian central nervous system makes up to ten thousand synaptic connections wi...
Ubiquitin-dependent receptor endocytosis and subsequent endocytic sorting to the lysosome for degrad...
My dissertation research focused on studying activity-dependent protein degradation in neurons prima...
The lysosome is canonically known as a major organelle for protein degradation and nutrient sensing ...
Lysosomes have traditionally been viewed as degradative organelles, though a growing body of evidenc...
Abstract: Compartmentalization of the membrane is essential for cells to perform highly specific tas...
Mechanisms of local protein quality control in the presynaptic nerve terminal remain largely unknown...
Cellular compartmentalization and intracellular transport mechanisms are important to establish and ...
Cellular compartmentalization and intracellular transport mechanisms are important to establish and ...
Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spa...
Synapses are often far from their cell bodies and must cope largely independently with dysfunctional...
Like all cells, neurons are made of proteins that have characteristic synthesis and degradation prof...
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