Four and a half LIM domain protein 2 (Fhl2) is an intracellular adaptor molecule with a high protein protein interaction capacity. It acts as a modulator of several signaling molecules in the cytosol and as a cofactor of transcription in the nucleus. Recent studies suggest the role of Fhl2 in tissue repair and the anti-inflammatory response. Herein, we show that Fhl2-deficient mice develop a more severe psoriatic arthritis disease under induction of the inducible human tumor necrosis factor (hTNF) transgene than wild-type mice. The disease was accompanied by increased infiltration of activated macrophages and T regulatory cells in skin and digit joints as well as by increased expression of matrix metalloproteases and bone-specific proteases...
Lipocalin 2 (Lcn2), a 25KDa innate immune protein, known to be dramatically up regulated in various ...
The nuclear receptor Nur77 is an early response gene that is induced by diverse extracellular signal...
Psoriasis is an autoimmune disorder in which overactive keratinocytes trigger the inflammatory respo...
Fibrogenesis is usually initiated when regenerative processes have failed and/or chronic inflammatio...
A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mic...
<div><p>Fibrogenesis is usually initiated when regenerative processes have failed and/or chronic inf...
International audienceFour-and-a-half LIM-only protein 2 (FHL2) is an important mediator in many sig...
International audienceZdhhc family genes are composed of 24 members that regulate palmitoylation, a ...
International audienceTransforming growth factor β1 (TGF-β1) is a master cytokine in many biological...
International audienceWe showed previously that Lyn is a substrate for caspases, a family of cystein...
Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important c...
Psoriatic arthritis (PsA) is a seronegative, inflammatory joint disease associated with psoriasis. I...
To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulate...
Psoriasis is a common immune-mediated, chronic, inflammatory skin disease that affects approximately...
Deficiency in the deubiquitinating enzyme A20 causes severe inflammation in mice, and impaired A20 f...
Lipocalin 2 (Lcn2), a 25KDa innate immune protein, known to be dramatically up regulated in various ...
The nuclear receptor Nur77 is an early response gene that is induced by diverse extracellular signal...
Psoriasis is an autoimmune disorder in which overactive keratinocytes trigger the inflammatory respo...
Fibrogenesis is usually initiated when regenerative processes have failed and/or chronic inflammatio...
A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mic...
<div><p>Fibrogenesis is usually initiated when regenerative processes have failed and/or chronic inf...
International audienceFour-and-a-half LIM-only protein 2 (FHL2) is an important mediator in many sig...
International audienceZdhhc family genes are composed of 24 members that regulate palmitoylation, a ...
International audienceTransforming growth factor β1 (TGF-β1) is a master cytokine in many biological...
International audienceWe showed previously that Lyn is a substrate for caspases, a family of cystein...
Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important c...
Psoriatic arthritis (PsA) is a seronegative, inflammatory joint disease associated with psoriasis. I...
To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulate...
Psoriasis is a common immune-mediated, chronic, inflammatory skin disease that affects approximately...
Deficiency in the deubiquitinating enzyme A20 causes severe inflammation in mice, and impaired A20 f...
Lipocalin 2 (Lcn2), a 25KDa innate immune protein, known to be dramatically up regulated in various ...
The nuclear receptor Nur77 is an early response gene that is induced by diverse extracellular signal...
Psoriasis is an autoimmune disorder in which overactive keratinocytes trigger the inflammatory respo...