Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part Ⅲ. Effects of chloroquine on tumor-bearing animals (Ehrlich ascites carcinoma and MH 134 ascites hepatoma)

Effects of fibroblast-inhibiting chloroquine diphosphate on ascites tumors such as Ehrlich ascites carcinoma and MH 134 ascites hepatoma weres tudied and the following results were obtained. 1) The survival of animals with Ehrlich ascites carcinoma was not prolonged but the tumor cells in the ascites tended to show a silght decrase. 2) The subcutaneous nodules of Ehrlich carcinoma and MH 134 hepatoma were not inhibited nor were the life span of tumor-bearing animals prolonged. 3) Implantantation of Ehrlich ascites carcinoma cells in vitro treated with the drug showed no difference from control