Add to ORKGAnti-NALL-1 rabbit IgG was incubated with NCS, an unique membrane-reactive anticancer antibiotic, in the presence of water-soluble carbodiimide. The resulting mixture contained NCS-immune IgG. The conjugates inhibited the growth and (3)H-TdR incorporation of human leukemia cell line (NALL-1) cells. A membrane immunofluorescent test with FITC-labeled rabbit anti-NCS and goat anti-rabbit IgG antibodies showed specific localization of NCS-immune IgG on NALL-1 cell surfaces. These results indicate that NCS-immune IgG retains both NCS and antibody activities, and NCS-immune IgG should be useful for cancer therapy
Neocarzinostatin (NCS) is an acidic protein with proven antitumor activity in experimental animals a...
Antibody–drug conjugates are increasingly being used for cancer therapy, but little is known about t...
Advances in cancer therapy have led to the exploitation of the biological differences between cancer...
Anti-NALL-1 rabbit IgG was incubated with NCS, an unique membrane-reactive anticancer antibiotic, in...
Rabbit xenoantiserum was produced against a human null cell type leukemia cell line (NALL-1), and im...
In the previous paper, we reported that Neocarzinostatin (NCS) could bind covalently to rabbit anti-...
The in vivo antitumor activity of NCS-immune IgG (NCS conjugated with rabbit IgG antibody against th...
A murine IgM monoclonal antibody specific for human Ia antigen was purified by Sephacryl S-300 chrom...
In vivo antitumor activity of anti-Ia monoclonal IgM antibody (H-2)-Neocarzinostatin (NCS) conjugate...
Neocarzinostain (NCS) was first used by Hiraki and his colleagues for induction chemotherapy in acut...
Human transferrin （Tf） was conjugated with the anticancer polypeptide, neocar- zinostatin （NCS）, by ...
A new strategy was shown for the manipulation of autoantibody production in humans. Antiidiotypic an...
Since tumor-antitumor agent-host correlation must be considered in the treatment of neoplasms, the q...
Malignant transformation of epithelial cells is frequently associated with the alteration of glycosy...
Antibody-drug conjugates (ADCs) have become a promising class of antitumor agents with four conjugat...
Neocarzinostatin (NCS) is an acidic protein with proven antitumor activity in experimental animals a...
Antibody–drug conjugates are increasingly being used for cancer therapy, but little is known about t...
Advances in cancer therapy have led to the exploitation of the biological differences between cancer...
Anti-NALL-1 rabbit IgG was incubated with NCS, an unique membrane-reactive anticancer antibiotic, in...
Rabbit xenoantiserum was produced against a human null cell type leukemia cell line (NALL-1), and im...
In the previous paper, we reported that Neocarzinostatin (NCS) could bind covalently to rabbit anti-...
The in vivo antitumor activity of NCS-immune IgG (NCS conjugated with rabbit IgG antibody against th...
A murine IgM monoclonal antibody specific for human Ia antigen was purified by Sephacryl S-300 chrom...
In vivo antitumor activity of anti-Ia monoclonal IgM antibody (H-2)-Neocarzinostatin (NCS) conjugate...
Neocarzinostain (NCS) was first used by Hiraki and his colleagues for induction chemotherapy in acut...
Human transferrin （Tf） was conjugated with the anticancer polypeptide, neocar- zinostatin （NCS）, by ...
A new strategy was shown for the manipulation of autoantibody production in humans. Antiidiotypic an...
Since tumor-antitumor agent-host correlation must be considered in the treatment of neoplasms, the q...
Malignant transformation of epithelial cells is frequently associated with the alteration of glycosy...
Antibody-drug conjugates (ADCs) have become a promising class of antitumor agents with four conjugat...
Neocarzinostatin (NCS) is an acidic protein with proven antitumor activity in experimental animals a...
Antibody–drug conjugates are increasingly being used for cancer therapy, but little is known about t...
Advances in cancer therapy have led to the exploitation of the biological differences between cancer...