The BHL and multiple nodular shadows with well-defined margin in a case of sarcoidosis

In a recent study, radiologic and pathologic examination of inflated and fixed lung specimens proved useful in the diagnosis of diffuse pulmonary diseases. In general, the margin of the nodular shadow is believed to be ill-defined in cases of sarcoidosis. Our patient was 47-year-old man, who has worked as a stone miner for 16 years. Chest radiography and CT revealed BHL and multiple nodular shadows with well-defined margins throughout the lung field. Those shadows were less than 1cm in diameter. TBLB showed epithelioid granulomas around the double refractile crystals. The finding suggests that the formation of epithelioid cell granuloma is related to silicate particles