While the notion that injecting fluids into the subsurface can reactivate faults by reducing frictional resistance is well established, the ensuing evolution of the slip is still poorly understood. What controls whether the induced slip remains stable and confined to the fluid-affected zone or accelerates into a runaway earthquake? Are there observable indicators of the propensity to earthquakes before they happen? Here, we investigate these questions by modeling a unique fluid-injection experiment on a natural fault with laboratory-derived friction laws. We show that a range of fault models with diverging stability with sustained injection reproduce the slip measured during pressurization. Upon depressurization, however, the most unstable ...