Vitamin K prophylaxis for preterm infants: A randomized, controlled trial of 3 regimens
- Clarke, Paul
- Mitchell, Simon J.
- Wynn, Robert
- Sundaram, Shanmuga
- Speed, Valerie
- Gardener, Elizabeth
- Roeves, Donna
- Shearer, Martin J.
DOIAbstract
OBJECTIVE. Preterm infants may be at particular risk from either inadequate or excessive vitamin K prophylaxis. Our goal was to assess vitamin K status and metabolism in preterm infants after 3 regimens of prophylaxis. METHODS. Infants <32 weeks' gestation were randomized to receive 0.5 mg (control) or 0.2 mg of vitamin K1 intramuscularly or 0.2 mg intravenously after delivery. Primary outcome measures were serum vitamin K1, its epoxide metabolite (vitamin K1 2,3-epoxide), and undercarboxylated prothrombin assessed at birth, 5 days, and after 2 weeks of full enteral feeds. Secondary outcome measures included prothrombin time and factor II concentrations. RESULTS. On day 5, serum vitamin K1 concentrations in the 3 groups ranged widely (2.9-3...
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