A study on coagulation profile of patients thrombolysed with streptokinase in acute st-elevation myocardial infarction

Introduction: a study on coagulation profile of patients thrombolysed with streptokinase in acute st-elevation myocardial infarction.aims and objectives of study1.To find the changes in the coagulation system after thrombolysis with streptokinase in st elevation myocardial infarction. 2.To postulate about the timing of starting heparinisation after thrombolysis with streptokinase in st elevation myocardial infarction. Materials and methods- is a cross sectional observational study of patients admitted with acute st elevation myocardial infarction(stemi) who were candidates for thrombolysis. Coagulation assay protocol-Whole blood is collected at baseline and at intervals of 3, 6, & 9hrs following initiation of thrombolysis. Results and conclusion: Early heparinisation may be considered in those patients who have non resolving st segment 90 minutes after thrombolysis , or those patients who have continuing pain even after thrombolysis..A significant correlation was found between aptt at 6hours and aptt at 9 hours that is patients who were in the therapeutic range at the end of 6 hours were also maintained at the end of 9 hours probably due to heparinisation at the end of 6 hours after thrombolysis.3.There is suboptimal  anticoagulation in MI. Keywords: coagulation,myocardial,CAD,factors,burden