This paper is forthcoming as a chapter in the «Handbook of Research on Entrepreneurship and Aging» edited by Charlie Karlsson, Mikaela Backman and Orsa Kekezi (to be published in July 2019 with Edward Elgar Publishing Inc.).The traditional understanding of entrepreneurship is biased towards certain population groups and specific locations. Yet the literature points to a much more diverse perspective on entrepreneurship and regional development. In this paper, we argue that regional characteristics such as the extent to which a region faces demographic change (population growth or decline, population ageing, emigration of youth, etc.) may exert a strong influence both on the individual propensity to start a business and the aggregate numbers...