International audienceFood odours are major determinants for food choice; their detection is influenced by nutritional status. Among different metabolic signals, insulin plays a major role in food intake regulation. The aim of the present study was to investigate a potential role of insulin in the olfactory mucosa (OM), using ex vivo tissues and in vitro primary cultures. We first established the expression of insulin receptor (IR) in rat olfactory mucosa. Transcripts of IR-A and IR-B isoforms, as well as IRS-1 and IRS-2, were detected in OM extracts. Using immunocytochemistry, IR protein was located in olfactory receptor neurones, sustentacular and basal cells and in endothelium of the lamina propria vessels. Moreover, the insulin binding ...
Sixty-five percent of Americans are over-weight. While the neuroendocrine controls of energy homeost...
International audienceThe Zucker fa/fa rat has been widely used as an animal model to study obesity,...
International audienceIn the brain, glucose homeostasis of extracellular fluid is crucial to the poi...
International audienceFood odours are major determinants for food choice; their detection is influen...
Insulin is involved in multiple regulatory mechanisms, including body weight and food intake, and pl...
Insulin is involved in multiple regulatory mechanisms, including body weight and food intake, and pl...
Olfactory perception determines food selection behavior depending on energy homeostasis and nutritio...
Insulin is an important peptide hormone that regulates food intake and olfactory function. While a m...
IRS-1 is phosphorylated on tyrosine residues after insulin insulin receptor mRNA in neuron cell bodi...
Background. Adiponectin (APN) is an adipocyte-derived hormone that has peripheral beneficial effects...
International audienceThe mammalian olfactory mucosa (OM) is continually renewed throughout life. Ow...
International audienceOlfaction influences food choice and intake. Conversely, the nutritional and m...
Obesity constitutes a global health care problem, and often eating habits are to blame. For interven...
Obesity constitutes a global health care problem, and often eating habits are to blame. For interven...
In mammals, the sense of smell is modulated by the status of satiety, which is mainly signaled by bl...
Sixty-five percent of Americans are over-weight. While the neuroendocrine controls of energy homeost...
International audienceThe Zucker fa/fa rat has been widely used as an animal model to study obesity,...
International audienceIn the brain, glucose homeostasis of extracellular fluid is crucial to the poi...
International audienceFood odours are major determinants for food choice; their detection is influen...
Insulin is involved in multiple regulatory mechanisms, including body weight and food intake, and pl...
Insulin is involved in multiple regulatory mechanisms, including body weight and food intake, and pl...
Olfactory perception determines food selection behavior depending on energy homeostasis and nutritio...
Insulin is an important peptide hormone that regulates food intake and olfactory function. While a m...
IRS-1 is phosphorylated on tyrosine residues after insulin insulin receptor mRNA in neuron cell bodi...
Background. Adiponectin (APN) is an adipocyte-derived hormone that has peripheral beneficial effects...
International audienceThe mammalian olfactory mucosa (OM) is continually renewed throughout life. Ow...
International audienceOlfaction influences food choice and intake. Conversely, the nutritional and m...
Obesity constitutes a global health care problem, and often eating habits are to blame. For interven...
Obesity constitutes a global health care problem, and often eating habits are to blame. For interven...
In mammals, the sense of smell is modulated by the status of satiety, which is mainly signaled by bl...
Sixty-five percent of Americans are over-weight. While the neuroendocrine controls of energy homeost...
International audienceThe Zucker fa/fa rat has been widely used as an animal model to study obesity,...
International audienceIn the brain, glucose homeostasis of extracellular fluid is crucial to the poi...