The first example of catalytic, enantioselective hypervinylogous Mukaiyama aldol reaction (HVMAR) involving multiply unsaturated 2-silyloxyindoles is reported. The reaction utilizes a chiral Lewis base-catalyzed Lewis acid-mediated technology to deliver homoallylic 3-polyenylidene 2-oxindoles with extraordinary levels of regio-, enantio-, and geometrical selectivity. This work highlights a subtle yet decisive influence of the indole N-substituents on the propagation of the vinylogous reactivity space of the donor substrates up to ten bonds away from the origin of the vinylogy effect. Analysis of the 13C NMR chemical shifts of the C-ω remote site within homologous silyloxyindole donors enabled rationalization of the results and easy qua...
Protected aldols (i.e., true aldols derived from aldehydes) with either syn- or anti- stereochemistr...
The vinylogous Mukaiyama aldol reaction (VMAR) allows efficient access to larger segments for comple...
Touched for the very first time! It is herein highlighted how acetaldehyde silyl enol ethers undergo...
The first example of catalytic, enantioselective hypervinylogous Mukaiyama aldol reaction (HVMAR) in...
We introduce novel 3-alkenyl-2-silyloxyindole nucleophiles and demonstrate their utility by developi...
Denmark’s chiral bisphosphoramide/silicon tetrachloride system performs as an excellent Lewis base-L...
Virtually perfect transmittal of the enolate reactivity up to five conjugated double bonds from the ...
A practical, catalytic and enantioselective vinylogous Mukaiyama aldol reaction between 2-...
A versatile procedure for the gamma-vinylogous aldol reaction of the dioxinone-derived silyl enoleth...
A vinylogous, silylative, and direct variant of the venerable Mukaiyama aldol reaction has been deve...
The direct vinylogous aldol reaction of α-substituted α,β-unsaturated aldehydes with isatins is desc...
This review describes the use of catalytic asymmetric aldol reactions of silyl enol ethers and silyl...
The chemical synthesis of organic molecules involves, at its very essence, the creation of carbon-ca...
Mukaiyama aldol, Mannich, and Michael reactions are arguably amongst the most important C–C bond for...
316 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.The double diastereodifferent...
Protected aldols (i.e., true aldols derived from aldehydes) with either syn- or anti- stereochemistr...
The vinylogous Mukaiyama aldol reaction (VMAR) allows efficient access to larger segments for comple...
Touched for the very first time! It is herein highlighted how acetaldehyde silyl enol ethers undergo...
The first example of catalytic, enantioselective hypervinylogous Mukaiyama aldol reaction (HVMAR) in...
We introduce novel 3-alkenyl-2-silyloxyindole nucleophiles and demonstrate their utility by developi...
Denmark’s chiral bisphosphoramide/silicon tetrachloride system performs as an excellent Lewis base-L...
Virtually perfect transmittal of the enolate reactivity up to five conjugated double bonds from the ...
A practical, catalytic and enantioselective vinylogous Mukaiyama aldol reaction between 2-...
A versatile procedure for the gamma-vinylogous aldol reaction of the dioxinone-derived silyl enoleth...
A vinylogous, silylative, and direct variant of the venerable Mukaiyama aldol reaction has been deve...
The direct vinylogous aldol reaction of α-substituted α,β-unsaturated aldehydes with isatins is desc...
This review describes the use of catalytic asymmetric aldol reactions of silyl enol ethers and silyl...
The chemical synthesis of organic molecules involves, at its very essence, the creation of carbon-ca...
Mukaiyama aldol, Mannich, and Michael reactions are arguably amongst the most important C–C bond for...
316 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.The double diastereodifferent...
Protected aldols (i.e., true aldols derived from aldehydes) with either syn- or anti- stereochemistr...
The vinylogous Mukaiyama aldol reaction (VMAR) allows efficient access to larger segments for comple...
Touched for the very first time! It is herein highlighted how acetaldehyde silyl enol ethers undergo...