The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers

Immunization activates multiple B cell clones that then partition into different fates. Robinson et al. show that the amount of BCL6 that an individual clone expresses affects its likelihood of progressing through the early immune response stages, with BCL6 amounts determining which clones enter germinal centers to contribute to long-term immunity.