Recent work has established that the paraventricular thalamus (PVT) is a central node in the brain reward-seeking pathway. This role is mediated in part through projections from hypothalamic peptide transmitter systems such as cocaine- and amphetamine-regulated transcript (CART). Consistent with this proposition, we previously found that inactivation of the PVT or infusions of CART into the PVT suppressed drug-seeking behavior in an animal model of contingent cocaine self-administration. Despite this work, few studies have assessed how the basic physiological properties of PVT neurons are influenced by exposure to drugs such as cocaine. Further, our previous work did not assess how infusions of CART, which we found to decrease cocaine-seeki...
We have previously demonstrated that cocaine- and amphetamine-regulated transcript (CART) peptide co...
Cocaine addicts display increased sensitivity to drug-associated cues, due in part to changes in the...
Addiction is characterized by a recurrent pattern of relapse to drug seeking and drug use. This beha...
Background: Cocaine- and amphetamine-regulated transcript (CART) has been demonstrated to play a rol...
Cocaine- and amphetamine-regulated transcript (CART) has been demonstrated to play a role in regulat...
doi: 10.3389/fnbeh.2014.00280 Electrophysiological characteristics of paraventricular thalamic (PVT)...
The hypothalamus is a critical controller of homeostatic responses and plays a fundamental role in r...
Ventral pallidum (VP) neurons exhibit changes in firing rate (FR) immediately prior to and/or follo...
International audienceBased on neuro-imaging studies in cocaine-addicted humans, it is hypothesized ...
The thalamus is considered an important interface between the ventral striatopallidum and the dorsal...
Research Doctorate - Doctor of Philosophy (PhD)Over the past decade, two hypothalamic neuropeptides,...
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive....
To examine the mechanisms of drug relapse, we first established a model for cocaine IVSA (intravenou...
Suppression of dangerous or inappropriate reward-motivated behaviors is critical for survival, where...
The globus pallidus external segment (GPe) acts as a gatekeeper of initial cocaine-induced behaviora...
We have previously demonstrated that cocaine- and amphetamine-regulated transcript (CART) peptide co...
Cocaine addicts display increased sensitivity to drug-associated cues, due in part to changes in the...
Addiction is characterized by a recurrent pattern of relapse to drug seeking and drug use. This beha...
Background: Cocaine- and amphetamine-regulated transcript (CART) has been demonstrated to play a rol...
Cocaine- and amphetamine-regulated transcript (CART) has been demonstrated to play a role in regulat...
doi: 10.3389/fnbeh.2014.00280 Electrophysiological characteristics of paraventricular thalamic (PVT)...
The hypothalamus is a critical controller of homeostatic responses and plays a fundamental role in r...
Ventral pallidum (VP) neurons exhibit changes in firing rate (FR) immediately prior to and/or follo...
International audienceBased on neuro-imaging studies in cocaine-addicted humans, it is hypothesized ...
The thalamus is considered an important interface between the ventral striatopallidum and the dorsal...
Research Doctorate - Doctor of Philosophy (PhD)Over the past decade, two hypothalamic neuropeptides,...
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive....
To examine the mechanisms of drug relapse, we first established a model for cocaine IVSA (intravenou...
Suppression of dangerous or inappropriate reward-motivated behaviors is critical for survival, where...
The globus pallidus external segment (GPe) acts as a gatekeeper of initial cocaine-induced behaviora...
We have previously demonstrated that cocaine- and amphetamine-regulated transcript (CART) peptide co...
Cocaine addicts display increased sensitivity to drug-associated cues, due in part to changes in the...
Addiction is characterized by a recurrent pattern of relapse to drug seeking and drug use. This beha...