Genome-wide association analysis identifies six new loci associated with forced vital capacity
- Loth, Daan W.
- Artigas, María Soler
- Lee, Mi Kyeong
- Scott, Rodney J.
- Karrasch, Stefan
- Grallert, Harald
- Gaddis, Nathan C.
- Starr, John M.
- Wijmenga, Cisca
- Minster, Ryan L.
- Lederer, David J.
- Pekkanen, Juha
- Gyllensten, Ulf
- Strachan, David P.
- Campbell, Harry
- Morris, Andrew P.
- Gläeser, Sven
- Hammond, Christopher J.
- Burkart, Kristin M.
- Beilby, John
- Kritchevsky, Stephen B.
- Gucinason, Vilmundur
- Hancock, Dana B.
- Williams, O. Dale
- James, Alan L.
- Polasek, Ozren
- Zemunik, Tatijana
- Kolcic, Ivana
- Petrini, Marcy F.
- Wjst, Matthias
- Kim, Woo Jin
- Porteous, David J.
- Scotland, Generation
- Smith, Blair H.
- Viljanen, Anne
- Huffman, Jennifer E.
- Heliovaara, Markku
- Attia, John R.
- Sayers, Ian
- Hampel, Regina
- Gieger, Christian
- Deary, Ian J.
- Boezen, H. Marike
- Newman, Anne
- Jarvelin, Marjo-Riitta
- Wilson, James F.
- Vitart, Veronique
- Lind, Lars
- Stricker, Bruno H.
- Teumer, Alexander
- Spector, Timothy D.
- Melén, Erik
- Peters, Marjolein J.
- Lange, Leslie A.
- Barr, R. Graham
- Bracke, Ken R.
- Verhamme, Fien M.
- Ramasamy, Adaikalavan
- Sung, Joohon
- Hiemstra, Pieter S.
- Cassano, Patricia A.
- Sood, Akshay
- Hayward, Caroline
- Dupuis, Josée
- Hall, Ian P.
- Brusselle, Guy G.
- Tobin, Martin D.
- London, Stephanie J.
- Wareham, Nicholas J.
- Kaprio, Jaakko
- Wang, Xin-Qun
- Trochet, Holly
- Gharib, Sina A.
- Kähönen, Mika
- Flexeder, Claudia
- Albrecht, Eva
- Lopez, Lorna M.
- de Jong, Kim
- Thyagarajan, Bharat
- Alves, Alexessander Couto
- Enroth, Stefan
- Omenaas, Ernst
- Joshi, Peter K.
- Wain, Louise V.
- Fall, Tove
- Viñuela, Ana
- Launer, Lenore J.
- Loehr, Laura R.
- Fornage, Myriam
- Li, Guo
- Wik, Jemma B.
- Tang, Wenbo
- Manichaikul, Ani
- Lahousse, Lies
- Franceschini, Nora
- Harris, Tamara B.
- North, Kari E.
- Rudnicka, Alicja R.
- Hui, Jennie
- Gu, Xiangjun
- Lumley, Thomas
- Wright, Alan F.
- Hastie, Nicholas D.
- Campbell, Susan
- Kumar, Rajesh
- Koch, Beate
- Pin, Isabelle
- Scott, Robert A.
- Pietilainen, Kirsi H.
- Surakka, Ida
- Liu, Yongmei
- Holliday, Elizabeth G.
- Schulz, Holger
- Heinrich, Joachim
- Davies, Gail
- Vonk, Judith M.
- Pottinger, Tess D.
- Wojczynski, Mary
- Pouta, Anneli
- Johansson, Åsa
- Wild, Sarah H.
- Ingelsson, Erik
- Rivadeneira, Fernando
- Vöezke, Henry
- Hysi, Pirro G.
- Eiriksdottir, Gudny
- Morrison, Alanna C.
- Smith, Albert Vernon
- Rotter, Jerome I.
- Gao, Wei
- Postma, Dirkje S.
- White, Wendy B.
- Rich, Stephen S.
- Hofman, Albert
- Aspelund, Thor
- Couper, David
- Smith, Lewis J.
- Psaty, Bruce M.
- Duan, Qing
- Lohman, Kurt
- Burchard, Esteban G.
- Uitterlinden, André G.
- Garcia, Melissa
- Joubert, Bonnie R.
- McArdle, Wendy L.
- Musk, A. Bill
- Hansel, Nadia
- Heckbert, Susan R.
- Zgaga, Lina
- Oldmeadow, Chris
- van Meurs, Joyce B. J.
- Navarro, Pau
- Rudan, Igor
- Oh, Yeon-Mok
- Redline, Susan
- Jarvis, Deborah L.
- Zhao, Jing Hua
- Rantanen, Taina
- O'Connor, George T.
- Ripatti, Samuli
DOIAbstract
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (<i>P</i> < 5 × 10<sup>−8</sup>) with FVC in or near <i>EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX</i> and <i>KCNJ2</i>. Two loci previously associated with spirometric measures (<i>GSTCD</i> and <i>PTCH1</i>) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individ...
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