Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia

Milne, Elizabeth
Greenop, Kathryn R.
Scott, Rodney J.
Bailey, Helen D.
Attia, John
Dalla-Pozza, Luciano
de Klerk, Nicholas H.
Armstrong, Bruce K.

Open link

Publication date

January 2012

DOI

10.1093/aje

Publisher

Oxford University Press

Journal

ISSN:0002-9262

Abstract

The association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated in an Australian population-based case-control study that included 388 cases and 868 controls aged <15 years, recruited from 2003 to 2006. Both of the child’s parents provided information about their smoking habits for each year from age 15 years to the child’s birth. Data were analyzed by logistic regression. Maternal smoking was not associated with risk of childhood ALL, but the odds ratio for paternal smoking of ≥15 cigarettes per day around the time of the child’s conception was 1.35 (95% confidence interval: 0.98, 1.86). The associations between parental smoking risk of childhood ALL did not differ substantially by immunop...