CLINICAL AND IMMUNOLOGICAL CHARACTERISTIC OF ACUTE DIARRHEAL DISEASES IN CHILDREN

The issue of acute diarrheas among children has become even more urgent due to some climatic and social factors in Central Asia. It is characterized with wide-spread, an unfavorable course with the formation of a clinic syndrome of invasive diarrhea, severe complications and frequent transition to a chronic form. Our aim was comparative assessment of the clinical and immunological characteristics of acute diarrheal diseases in children. We monitored young children with acute intestinal infections with established etiology (n=212), unknown etiology (n=48) and healthy children (n=32). A prospective study was conducted using general clinical, bacteriological and statistical methods. We studied the clinical characteristics of acute diarrhea of bacterial origin, depending on the age of the children, the etiological factor, the nature of feeding. The disease in most patients proceeds in moderate and severe forms, recovery lasts up to 3-4 weeks, the pathogens are resistant to antibiotics, the widespread infection caused by Clostridium difficile is caused. The clinical picture of acute diarrhea in 97% of cases was manifested in a combined lesion of the gastrointestinal tract. The severity and adverse outcome were largely associated with extreme degrees of intoxication, severe electrolyte disturbances, the presence of primary and secondary immunodeficiency, and partially with background congenital pathology