The role of event related potentials in evaluation of subclinical cognitive dysfunction in epileptic patients

Nazliel, Bijen/0000-0002-6148-3814WOS: 000259225000005PubMed: 18795598Background/Aim : Cognitive dysfunction ill epileptic patients may develop due to the neurophysiological changes related to seizures or antiepileptic drugs. The aim of this study was to evaluate the cognitive dysfunction ill epileptic patients under antiepileptic drug therapy by the aid of event related potentials. Method: P300 latencies were obtained from F-z, C-z and P-z electrod positions from both epileptic patients (n = 40) and age and sex matched control group (n = 40). Epileptic patients were, classified either idiopathic primary generalized (IPGE) (n = 9) or secondary generalized epilepsy (SGE) (n = 31) based oil the ILAE classification The effect of epilepsy hype, treatment types (monotherapy/polytherapy), daily dosages and serum levels of antiepileptic drugs, age at onset and EEG abnormalities oil P300 latencies were studied. Results : P300 latencies were longer ill the epileptics when compared to controls (P 0.05). Antiepileptic drug subgroups revealed variable effects on ERP latencies. Conclusion : We believe P300 latencies may have all important role in the evaluation of subclinical cognitive dysfunction in epileptic patients treated with antiepileptic drags