Preparation and Drug-Release Behavior of Minocycline-Loaded Poly[hydroxyethyl methacrylate-co-poly(ethylene glycol)-methacrylate] Films

Batislam, Ertan/0000-0002-7493-4573WOS: 000263761100054In this work, biocompatible hydrogel matrices for wound-dressing materials and controlled drug-release systems were prepared from poly[hydroxyethyl methacrylate-co-poly(ethylene glycol)-methacrylate] [p(HEMA-co-PEG-MA] films via UV-initiated photopolymerization. The characterization of the hydrogels was conducted with swelling experiments, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis (differential scanning calorimetry), and contact-angle studies. The water absorbency of the hydrogel films significantly changed with the change of the medium pH from 4.0 to 7.4. The thermal stability of the copolymer was lowered by an increase in the ratio of poly(ethylene glycol) (PEG) to methacrylate (MA) in the film structure. Contact-angle measurements on the surface of the p(HEMA-co-PEG-MA) films demonstrated that the copolymer gave rise to a significant hydrophilic surface in comparison with the homopolymer of 2-hydroxyethyl methacrylate (HEMA). The blood protein adsorption was significantly reduced on the surface of the copolymer hydrogels in comparison with the control homopolymer of HEMA. Model antibiotic (i.e., minocycline) release experiments were performed in physiological buffer saline solutions with a continuous flow release system. The amount of minocycline release was shown to be dependent on the HEMA/PEG-MA ratio. The hydrogels have good antifouling properties and therefore are suitable candidates for wound dressing and other tissue engineering applications. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 112:1012-1020, 200