Lipid peroxidation and the antioxidant capacity of dialysis patients: The effects of a single hemodialysis session with different dialysis membranes

Objective: To estimate lipid peroxidation and the antioxidant defense capacity of dialysis patients and the effects of different types of dialysis membranes on these parameters. Methods: Fifty-four dialysis patients and 30 healthy controls were included in this study. Ten of the dialysis patients were on continuous ambulatory peritoneal dialysis treatment and the rest were on hemodialysis with either polycarbonate membrane (n=10) or hemophan membrane (n=34). Polycarbonate membranes were switched with a vitamin E-coated dialyzer in the subsequent dialysis session. Total antioxidant status and malondialdehyde levels were studied to determine the antioxidant defense capacity and lipid peroxidation, respectively. before and after the dialysis session. Results: Plasma total antioxidant status levels were lower(1.51±0.2 mmol/1 vs. 1.75±0.20 mmol/1 p<0.05) and malondialdehyde levels were higher (2.2±1.17 nmol/ml vs. 0.60±0.20 nmol/ml p