The impact of allogenic red cell transfusion and coated bypass circuit on the inflammatory response during cardiopulmonary bypass: A randomized study

PubMed: 18801802Objective: This study is designed to determine and compare the effects of transfusion and coated circuits on the inflammatory response during cardiopulmonary bypass. Methods: Forty patients were randomized into two groups according to the type of extracorporeal circuit used and later prospectively enrolled into two subgroups according to the need for red cell transfusion during CPB (leading to 4 groups - 10 patients per group; group 1: with no transfusion and standard oxygenator, group 2: with transfusion and standard oxygenator, group 3: with no transfusion and coated oxygenator, group 4: with transfusion and coated oxygenator). Serum lactate, interleukin 6, human tumor necrosis factor alpha (TNF-?), D-dimer and CRP levels were measured at three time points (T1: start of CPB, T2: before removal of aortic cross-clamp, T3: 45 min after the completion of proximal anastomoses). Protein adsorption of oxygenator fibers was measured. Outcome parameters were recorded. Results: Interleukin 6, TNF-?, D-dimer and lactate levels increased at T2 and T3 in all groups (P