Add to ORKGWe describe a novel methylation-sensitive nucleic acid (RNA) probe which switches conformation according to its methylation status. When combined with a differential scanning fluorimetry technique, it enables highly sensitive and selective detection of demethylase activity at a single methylated-base level. The approach is highly versatile and may be adapted to a broad range of RNA demethylases
Methylation-sensitive single-strand conformation analysis (MS-SSCA) is a method of screening for met...
Epigenetics, is the study describes the (heritable) modifications in DNA structure that are not caus...
The AlkB family demethylases AlkB, FTO, and ALKBH5 recognize differentially methylated RNA/DNA subst...
Methylated bases in tRNA, rRNA and mRNA control a variety of cellular processes, including protein s...
N⁶-Methyladenosine (m6A) is currently one of the most intensively studied post-transcriptional modif...
High-resolution melting (HRM) analysis exploits the reduced thermal stability of DNA fragments that ...
High-resolution melting (HRM) analysis exploits the reduced thermal stability of DNA fragments that ...
Understanding how RNA works requires the coordinated use of diverse experimental approaches. Knowled...
DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is...
Methylation of RNA by methyltransferases is a phy-logenetically ubiquitous post-transcriptional modi...
N/O-methylation of DNA can be cytotoxic and mutagenic; therefore, enzymes that reverse DNA methylati...
DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is...
<div><p>DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methyl...
The discovery of small molecules targeting the > 80 enzymes that add (methyltransferases) or remove ...
RNA methylation is a ubiquitous post-transcriptional modification found in diverse RNA classes and i...
Methylation-sensitive single-strand conformation analysis (MS-SSCA) is a method of screening for met...
Epigenetics, is the study describes the (heritable) modifications in DNA structure that are not caus...
The AlkB family demethylases AlkB, FTO, and ALKBH5 recognize differentially methylated RNA/DNA subst...
Methylated bases in tRNA, rRNA and mRNA control a variety of cellular processes, including protein s...
N⁶-Methyladenosine (m6A) is currently one of the most intensively studied post-transcriptional modif...
High-resolution melting (HRM) analysis exploits the reduced thermal stability of DNA fragments that ...
High-resolution melting (HRM) analysis exploits the reduced thermal stability of DNA fragments that ...
Understanding how RNA works requires the coordinated use of diverse experimental approaches. Knowled...
DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is...
Methylation of RNA by methyltransferases is a phy-logenetically ubiquitous post-transcriptional modi...
N/O-methylation of DNA can be cytotoxic and mutagenic; therefore, enzymes that reverse DNA methylati...
DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is...
<div><p>DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methyl...
The discovery of small molecules targeting the > 80 enzymes that add (methyltransferases) or remove ...
RNA methylation is a ubiquitous post-transcriptional modification found in diverse RNA classes and i...
Methylation-sensitive single-strand conformation analysis (MS-SSCA) is a method of screening for met...
Epigenetics, is the study describes the (heritable) modifications in DNA structure that are not caus...
The AlkB family demethylases AlkB, FTO, and ALKBH5 recognize differentially methylated RNA/DNA subst...